Tpc2 interactome

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August undefined, 2024

SpletSWISS-MODEL Repository entry for Q8NHX9 (TPC2_HUMAN), Two pore channel protein 2. Homo sapiens (Human) Splet15. okt. 2005 · THOUSANDS OF INTERACTIONS: ON THE WAY TO PROTEOME-SCALE INTERACTOMES Large-scale Y2H screens for Helicobacter pylori ( 82 ), S. cerevisiae ( 6, 7 ), Drosophila melanogaster ( 9 ), C. elegans ( 10) and Homo sapiens ( 63, 83) have produced thousands of interaction pairs.

Two-pore channels as master regulators of membrane trafficking …

SpletTPC2, but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation. These outcomes required both TPC2 … Splet25. avg. 2014 · As a result, the identification of NAADP-TPC2 interactomes is currently an area of great interest (Figure 2), and proteomic characterisation has unsurprisingly … firestar map in the name of love

What is the Interactome? - News-Medical.net

SpletInteractome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones Joel C. Watts1,2.¤a, Hairu Huo1., Yu Bai1.¤b, Sepehr Ehsani1,2., Amy Hye Won1,2, Tujin Shi1, Nathalie Daude3, Agnes Lau3, Rebecca Young4, Lei Xu4, George A. Carlson4, David … Splet10. apr. 2024 · We show that TPC2 is required for intracellular Ca 2+ signaling in response to NAADP or to mTOR inhibition by rapamycin. In pulmonary arterial myocytes, rapamycin and NAADP evoked global Ca 2+ transients that … Splet20. feb. 2015 · The interactome collects all physical interactions between a cell’s molecular components. Proteins associated with the same disease form connected subgraphs, called disease modules, shown for multiple sclerosis (MS), peroxisomal disorders (PD), and rheumatoid arthritis (RA). firestar m40 review

Interactome: gateway into systems biology - Oxford Academic

Endo-Lysosomal Two-Pore Channels and Their Protein Partners

SpletView/Edit Mouse. Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene. [5] TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing … SpletIn a genomewide association study for variants associated with human pigmentation characteristics among 5,130 Icelanders, with follow-up analyses in 2,116 Icelanders and 1,214 Dutch individuals, Sulem et al. (2008) found that 2 coding variants in TPCN2, M484L ( 612163.0001) and G734E ( 612163.0002 ), were associated with blond versus brown hair ... firestar kits warrior catsSpletAs TPC2 is a cation channel for endocytotic membrane trafficking, TPCs contribute in trafficking LDL molecules for their breakdown and recycling. This primarily occurs within the liver. The degradation pathway causes LDL to end up in endosomes and lysosomes – where TPCs are located. The TPC mechanism once again allows the efflux of calcium ... firestar name

"SpletTPC2, but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular trafficking, and cellular pigmentation. These outcomes required both TPC2 … " - Tpc2 interactome

Tpc2 interactome

Uncovering disease-disease relationships through the incomplete interactome

Splet15. jan. 2015 · Established co-immunoprecipitation, mass spectrometry and proteomics analysis of interactomes for two-pore channels (TPCs) and calcium… Research Specialist at Department of Pharmacology - Aug 20061... SpletThe TPC interactome establishes a useful community resource as a “rosetta stone” for interrogating the cell biology of TPCs and their regulation. The dataset reveals a …

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Splet02. maj 2016 · TPC2 regulates the pH and size of melanosomes, thus controlling the amount of melanin produced. Abstract Melanin is responsible for pigmentation of skin … SpletThe importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated. Of particular note are two-pore channels

Splet16. feb. 2024 · SARS coronavirus 2 interactome. These page describe most significant functional host-virus interactions. Many more interactions have been suggested by large-scale or preliminary experiments and can be found in external resources. Host Protein. Spletsplice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus. Node Color colored nodes: query proteins and first shell of interactors white nodes: second shell of interactors Node Content empty nodes: proteins of unknown 3D structure filled nodes:

Splet24. avg. 2024 · Protein-protein complementation assay (PCA) This method is also used to study protein-protein interactions. In this method, a fluorescent protein is split in to two, and then fused to the N-or... Splet01. jul. 2024 · Accordingly, interactomes are compared and contrasted, and subsequently described in detail for TPC1, TPC2, TRPML1, and TRPML3. Major conclusions TPC …

SpletBy defining the TPC interactome, we provide a community resource that illuminates TPC complex regulation and resolves associations with... Interactomics, Pigmentation and …

SpletTPC2 has recently emerged as an intracellular ion channel of significant pathophysiological relevance, specifically in cancer, and interest in its role as an anti-cancer drug target has … ethw buySplet07. feb. 2014 · We show that TPC2 is activated by PI (3,5)P 2 and is Na + -permeable. We discovered profound regulation of TPC2 by Mg 2+ ions whereby cytosolic Mg 2+ selectively inhibits TPC2 outward current while lysosomal Mg 2+ modestly inhibits both the outward and inward currents. firestar likes wafflesSplet11. dec. 2024 · TCAs activate both TPC1 and TPC2 in a voltage-dependent manner, referred to as Ly sosomal Na+ channel V oltage-dependent A ctivators (LyNa-VAs). We also identified another compound which, like PI (3,5)P 2, activates TPC2 independent of voltage, suggesting the existence of agonist-specific gating mechanisms. ethw co to jestTwo-pore channels (TPCs) are a recently discovered family of endolysosomal ion channels, but their regulation is controversial. By defining the TPC interactome, we provide a community resource that illuminates TPC complex regulation and resolves associations with novel partners and processes. Physical interactions with endolysosomal trafficking ... firestar m43 reviewSplet12. avg. 2024 · Whilst rapamycin activation of TRPML1 is direct, activation of TPC2 is suggested to be indirect via inhibition of mTOR [ 59, 76, 79 ]. Protein regulators Other signalling inputs may interact with TPCs including protein kinases such as LRKK [ 80 ], JNK/p38 [ 81 ], mTOR [ 79] and the small GTPase, Rab7 [ 82 ]. firestar networkSplet12. mar. 2024 · Two-pore channels (TPCs) belong to the voltage-gated ion channel superfamily and function as a homodimer, with each subunit containing two homologous Shaker-like 6-TM repeats.TPC1 and TPC2 represent two major subfamilies of mammalian TPC channels, and have been subjected to extensive studies (Grimm et al., 2024; Patel, … firestar lifeSplet27. maj 2016 · We found that TPC2 serves as a negative regulator of pigmentation by increasing melanosomal membrane potential and acidity to decrease cellular melanin … ethw distribution