WebCTRCD may progress to heart failure over time.2 The incidence and degree of CTRCD depends on type of the used cancer drug, cumulative dose and (pre-)existing cardiovascular comorbidities.3. Currently, … WebBackground: Progress in the treatment of breast cancer has led to substantial improvement in survival, but at the cost of increased side effects, with cardiotoxicity being the most significant one. The commonly used definition is cancer therapeutics-related cardiac dysfunction (CTRCD), defined as a left ventricular ejection fraction reduction of > 10%, to …
Cancer Therapeutics-Related Cardiac Dysfunction - Insights …
WebMay 7, 2024 · CTRCD should be monitored in patients treated with ICIs by cardiac biomarkers and echocardiography, including LV-GLS. ICIs may increase the risk of CTRCD when used with cardiotoxic agents. Cancer Therapy-Related Cardiac Dysfunction in Patients Treated with a Combination of an Immune Checkpoint Inhibitor and Doxorubicin WebJul 29, 2024 · Cancer therapy-related cardiac dysfunction (CTRCD) is one of the most feared and undesirable side effects of chemotherapy, occurring in approximately 10% of the patients. It can be classified as direct (dose-dependent vs dose-independent) or indirect, … city auto used trucks
Echocardiography and cancer therapeutics-related cardiac dysfunction
WebAug 22, 2024 · For relative changes versus a baseline value (nine studies), cutoff values ranged from 2.3% to 15.9%, with a greater decrease linked to a 16-fold higher risk of CTRCD (OR, 15.82; 95% CI, 5.84-42.85; area under the HSROC, 0.86; 95% CI, 0.83-0.89). The cut-off value reported varied widely across studies. Last, funnel plot asymmetry … WebAug 2, 2024 · From the distribution of de novo CTRCD and mortality, cancer patients with de novo CTRCD were enriched in orange and green subgroups across multiple time points . However, patients in subgroups purple and orange show the worse mortality within 10 years of cancer therapy initiation ( Fig 3 ), consistent with survival analysis in the combined ... WebOct 3, 2024 · These findings point the superiority of Myocardial Work for early type 1 CTRCD detection in comparison to the current diagnostic tools. Additionally, we suggest the add-on value of ΔWW on top of ΔGLS quantification for better patient risk stratification. These are promising results for better clinical surveillance of cardiac function during ... city auto wholesale llc